Anti-COPS4 Antibody

The target COPS4 is the fourth subunit of the COP9 signalosome, a conserved multi-protein complex that governs cullin-RING ligase activity through deneddylation and modulates NF-κB, p53, and cell-cycle checkpoint signalling. This polyclonal reagent from Antibodies.com is raised in rabbit and purified to recognize the human, mouse, and rat orthologues of the protein, making it appropriate for cross-species comparative work in standard immunoblotting workflows.

Provided as 200 µl of unconjugated IgG in a liquid format, the antibody supports Western Blot detection of endogenous COPS4 from cell and tissue lysates. Aliquot upon receipt and refrigerate to preserve activity; avoid repeated freeze-thaw cycles. For short-term use, the vial may be kept on ice during the procedure and protected from light when not in use.

Researchers investigating signalosome assembly, neddylation balance, or the crosstalk between CSN and the ubiquitin–proteasome system can use this reagent to probe expression across developmental stages, stress responses, or disease models where COP9 signalosome integrity has been implicated, including certain cancers and DNA-damage response studies.