Anti-Connexin 43 (Ab-367) Antibody

Connexin 43 is a ~43 kDa gap junction channel protein encoded by GJA1, and this rabbit polyclonal reagent from Antibodies.com selectively targets the phosphorylated serine 367 epitope on its C-terminal regulatory domain. Supplied as 100 µL of unconjugated antisera, the antibody is validated for western blot and immunohistochemistry on human, mouse, and rat samples, making it a practical choice for studies of cardiac, neural, and epithelial tissue where Cx43 phosphorylation modulates gap junctional communication. Aliquot on receipt and store at -20 °C, avoiding repeated freeze-thaw cycles to preserve the affinity-purified polyclonal population. Researchers use this reagent to track phosphorylation-dependent changes in gap junction assembly, for example following ischemia, oxidative challenge, or kinase inhibition in cell culture and in vivo models. The polyclonal host response yields broad recognition of the modified epitope across species, and the unconjugated format allows flexible secondary antibody pairing for fluorescent, chromogenic, or chemiluminescent detection in immunoblot and tissue section workflows.