Anti-COLQ Antibody

This polyclonal reagent from Antibodies.com targets the collagen-like tail subunit of asymmetric acetylcholinesterase, a protein critical for anchoring AChE at the neuromuscular junction's synaptic basal lamina. Mutations in COLQ underlie congenital myasthenic syndrome, making reliable detection valuable for studies of synaptic organization and related neuromuscular pathology.

The antibody is raised in rabbit, presented unconjugated, and validated for Western blot across human, mouse, and rat sample lysates. It is supplied at 1 mg/ml in phosphate buffered saline containing 15 mM sodium azide at approximately pH 7.2, and ships in a 100 µl vial. For handling, refrigerate at approximately 4 °C, protect from light, and minimize freeze-thaw cycles to preserve reagent activity. Researchers applying this antibody to skeletal muscle or neural tissue preparations can probe anchoring complex composition, AChE tail subunit abundance, and protein-level changes associated with COLQ-related disease models.