Anti-Collagen XX α1 Antibody

This Rabbit polyclonal antibody from Antibodies.com targets Collagen XXV alpha 1 (COL25A1), a transmembrane collagen originally identified as CLAC (collagen-like Alzheimer amyloid plaque component) and implicated in amyloid plaque pathology associated with Alzheimer's disease. The protein is expressed in neuronal tissue and has become a marker of interest in neurodegeneration and extracellular matrix studies.

Supplied as 50 µl of polyclonal antiserum raised in rabbit and unconjugated for flexible labelling, the reagent is validated for Western blot, immunohistochemistry, and immunofluorescence workflows. It cross-reacts with both human and mouse samples, supporting translational studies that move between patient-derived material and transgenic mouse models.

Common use cases include probing COL25A1 expression in brain tissue sections by IHC, detecting the protein in cell or tissue lysates by Western blot, and localising it by immunofluorescence in cultured neurons. The unconjugated format lets researchers pair the antibody with their preferred secondary reagent and detection strategy, whether chromogenic, fluorescent, or chemiluminescent.