Anti-Collagen VI α2 Antibody

Antibodies.com offers this rabbit polyclonal reagent raised against Collagen VI α2 (COL6A2), the alpha-2 chain that assembles with COL6A1 and COL6A3 into microfibrillar collagen VI found in the extracellular matrix of skeletal muscle, skin, and other connective tissues.

The unconjugated antibody is supplied as 50 µl of stock and has been validated for western blot and immunohistochemistry on human and mouse specimens. It supports studies of connective tissue biology, skeletal muscle architecture, and dermal matrix composition, and is a useful tool for research into collagen VI-related myopathies such as Bethlem myopathy and Ullrich congenital muscular dystrophy, both of which arise from mutations in COL6A2.

For best results, aliquot upon arrival and keep frozen; avoid repeated freeze-thaw cycles, and protect from light. Researchers can pair this reagent with anti-collagen VI α1 and α3 antibodies to map complete collagen VI microfibril distribution in tissue sections and to compare protein expression across normal and diseased samples.