Anti-Collagen VI α2 Antibody

Rabbit polyclonal antibody from Antibodies.com targeting the alpha-2 subunit of collagen VI (COL6A2), supplied as 100 µl of unconjugated antiserum. Validated for Western blot and immunohistochemistry on human and mouse samples, this reagent supports studies of extracellular matrix organization, basement membrane biology, and connective tissue development. COL6A2 assembles with COL6A1 and COL6A3 into microfibrillar networks that anchor fibrillar collagens and preserve skeletal muscle integrity, and the antibody is widely used to investigate Bethlem myopathy and Ullrich congenital muscular dystrophy, where COL6A2 mutations disrupt muscle fiber adhesion and drive progressive weakness. The polyclonal format increases the chance of recognizing multiple epitopes on the alpha-2 chain, useful when probing denatured lysates by WB and fixed tissue sections by IHC. For handling, refrigerate the vial upon arrival, aliquot to limit freeze-thaw cycles, and protect from light for long-term stability.