Anti-COLEC11 Antibody

The polyclonal antibody raised in rabbit targets human COLEC11, a secreted pattern recognition molecule of the collectin family that participates in lectin-pathway complement activation and in early craniofacial and skeletal morphogenesis. Researchers studying 3MC syndrome (Carnevale, Mingarelli, Malpuech, and Michels) use this reagent to investigate loss-of-function variants that disrupt collagen-like domain folding and downstream signaling. Each vial contains 100 µl of unconjugated IgG supplied by Antibodies.com, validated for western blot, immunohistochemistry, and flow cytometry workflows on human samples, with no cross-reactivity data reported for non-human species. Storage at -20 °C in single-use aliquots preserves activity across multiple freeze-thaw cycles, and the format suits immunoblotting of liver, kidney, and embryonic tissue lysates as well as surface-marker profiling in immune cell populations. The reagent is intended for research use only and is widely cited in studies of innate immunity, developmental biology, and rare congenital disorder mechanisms.