Anti-COL10A1 Antibody

Collagen Type X Alpha 1 (COL10A1) is a short-chain collagen selectively secreted by hypertrophic chondrocytes during endochondral ossification, and this unconjugated rabbit polyclonal IgG reagent from Antibodies.com enables its immunohistochemical localisation in Human, Mouse, and Rat tissues.

Because COL10A1 expression is tightly restricted to growth plate cartilage undergoing hypertrophy, the antibody functions as a marker for studies of skeletal development, fracture callus maturation, osteoarthritis progression, and the cartilage-to-bone transition. The unconjugated format allows flexible pairing with HRP- or fluorophore-conjugated secondaries in chromogenic IHC and immunofluorescence workflows.

Raised in rabbit and supplied as a polyclonal IgG in a 200 µl volume, the reagent is validated for IHC applications. Common use cases include labelling hypertrophic chondrocytes in murine growth plate sections, characterising cartilage pathology in rodent osteoarthritis models, and investigating Schmid-type metaphyseal chondrodysplasia, a skeletal disorder linked to COL10A1 mutations. The cross-reactivity profile covering human, mouse, and rat samples supports comparative work between clinical specimens and standard preclinical models.