Anti-Cofilin 2 Antibody

Raised in rabbit as a polyclonal reagent, this unconjugated primary antibody from Antibodies.com targets the muscle-specific actin-binding protein Cofilin 2 (CFL2), a roughly 19 kDa member of the ADF/cofilin family that regulates actin filament turnover in skeletal and cardiac muscle. The reagent is validated for western blot, immunohistochemistry, and immunofluorescence workflows on human samples, making it a useful tool for studies of sarcomere assembly, muscle differentiation, and investigations of nemaline myopathy type 5, where CFL2 loss-of-function mutations have been linked to congenital myopathies with characteristic rod-like inclusions.

Supplied as 100 µl of liquid in a single-use vial, the antibody is unconjugated, giving researchers flexibility with custom secondary labeling and direct assay development. Because Cofilin 2 expression is largely restricted to striated muscle, the reagent is most informative when applied to skeletal or cardiac tissue sections, cultured myotubes, or muscle-derived cell lysates, where it supports detection of endogenous Cofilin 2 alongside markers of actin cytoskeleton organization. Host Rabbit, Clonality Polyclonal, Conjugate Unconjugated, Reactivity Human, Target Cofilin 2.