Anti-CNTFR Antibody

CNTFR (Ciliary Neurotrophic Factor Receptor alpha) serves as the GPI-anchored binding subunit of the CNTF receptor complex, assembling with the signal-transducing proteins gp130 and LIFR-beta at the cell surface. This rabbit polyclonal antibody from Antibodies.com targets CNTFR for neuroscience and cytokine signaling research, where downstream JAK-STAT cascades—principally STAT3 phosphorylation—drive gene expression in motor neurons, astrocytes, and oligodendrocytes.

The unconjugated antibody is supplied at 100 µL volume and has been validated for Western Blot (WB) and Immunohistochemistry (IHC) applications across human, mouse, and rat samples. Researchers commonly use anti-CNTFR reagents to detect the receptor in tissue lysates by Western Blot, to visualize receptor distribution in fixed tissue sections by IHC, and to investigate cytokine signaling in neural development, glial biology, retinal ganglion cell survival, and models of neurodegenerative disease.

Because the unconjugated format leaves the primary antibody unlabelled, it pairs cleanly with many chromogenic or fluorescent secondary antibodies for tailored detection chemistry. For storage, aliquot upon receipt and freeze at -20 °C in working volumes to limit freeze-thaw cycles, with brief refrigeration at 4 °C for ongoing bench use.