Anti-CNP Antibody

Produced by Antibodies.com as a rabbit polyclonal IgG reagent, this unconjugated antibody recognizes 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP), a myelin-associated enzyme that serves as an early and reliable marker of oligodendrocyte differentiation in the central nervous system. Supplied as 200 µl of stock, it is validated for Western blot and cross-reacts with Human, Mouse, and Rat samples, supporting comparative work across standard laboratory models.

CNP expression rises at the onset of myelination and remains enriched in compact myelin sheaths throughout adulthood, which is why anti-CNP reagents are widely used to track oligodendrocyte lineage progression and to monitor myelin integrity in models of demyelination and remyelination. The antibody supports research into multiple sclerosis, leukodystrophies, traumatic brain injury, and schizophrenia-related neurobiology, where CNP levels are routinely measured in brain tissue lysates or primary oligodendrocyte cultures.

The polyclonal format recognizes multiple epitopes on the CNP target, improving signal robustness on Western blot when probing endogenous protein. For best results, refrigerate on receipt, aliquot to limit freeze-thaw cycles, and pair the primary with standard HRP or fluorescent secondary detection workflows.