Anti-CMTM3 Antibody

This unconjugated polyclonal reagent from Antibodies.com targets CMTM3 (CKLF-like MARVEL transmembrane domain-containing 3), a transmembrane protein implicated in immune cell regulation, EGFR pathway modulation, and tumor suppressor activity in several solid tissue contexts. Raised in rabbit, the antibody is supplied as 100 µl of liquid and is validated for western blot and ELISA workflows against human and monkey samples.

CMTM3 belongs to a conserved family bridging chemokine-like factor (CKLF) and MARVEL domain proteins, and altered expression has been reported in immune effector cells as well as in epithelial cancers where its loss correlates with proliferative signaling through retained EGFR surface stability. Researchers commonly deploy this reagent to probe CMTM3 abundance in lysates from cultured human cell lines and primate-derived tissues, to assess its role in lymphocyte signaling studies, and to screen recombinant expression constructs in heterologous systems.

Because the antibody is unconjugated and polyclonal, it gives researchers flexibility in secondary antibody pairing and is a strong match for immunoblot detection of endogenous CMTM3. The polyclonal format supports recognition of multiple epitopes on the target, useful when probing truncated isoforms or post-translationally modified forms. Aliquoting on receipt is recommended to limit freeze-thaw exposure of the 100 µl stock.