Anti-CLTC Antibody

Clathrin heavy chain (CLTC) is a major structural protein of cytoplasmic coated vesicles and a central player in receptor-mediated endocytosis, vesicle trafficking, and membrane recycling. This unconjugated rabbit polyclonal antibody from Antibodies.com is raised against the CLTC target and validated for Western blot and immunohistochemistry workflows using human, mouse, and rat samples. Each vial of 100 µl provides a primary reagent for probing endogenous clathrin expression across cultured cell lysates and fixed tissue sections. Investigators studying synaptic vesicle turnover, endocytic coat dynamics, and receptor internalization use anti-CLTC reagents to map clathrin-coated pit assembly, cargo selection, and lysosomal delivery. Cross-reactivity with three model species enables comparative studies in neuroscience, cancer cell biology, and drug uptake research, where clathrin-mediated endocytosis shapes receptor signaling and intracellular transport.