Anti-Clock Antibody

The CLOCK protein (Circadian Locomotor Output Cycles Kaput) is a core transcription factor in the mammalian circadian oscillator, and this polyclonal reagent from Antibodies.com is raised in rabbit to detect endogenous Clock expression across multiple model organisms. Validated for Western blot and immunohistochemistry workflows, the antibody recognizes human, mouse, and rat Clock, enabling cross-species studies of circadian gene regulation in neural, hepatic, and peripheral tissues.

Supplied as 100 µL of unconjugated antiserum, the reagent supports flexible secondary detection strategies, including HRP or fluorescent conjugates depending on the assay design. As a polyclonal preparation, the antibody binds multiple epitopes across the target, which helps maintain strong signal in both denatured Western blot membranes and fixed tissue sections prepared for IHC.

CLOCK partners with BMAL1 to drive transcription of Period (Per1/Per2) and Cryptochrome (Cry1/Cry2) genes, and altered expression has been linked in the literature to disrupted sleep-wake cycles, metabolic phenotypes, and tumor biology research. Investigators in chronobiology, neurodegeneration, and metabolic timing use this reagent to map Clock localization and abundance in tissue samples.