Anti-Cleaved-Notch 2 (D1733) Antibody

Generated against the neo-epitope exposed at aspartate 1733 of human Notch 2, this Antibodies.com polyclonal antibody detects the cleaved intracellular domain (NICD) that forms after gamma-secretase proteolysis. It serves as a direct readout of Notch 2 receptor activation in Western blot, immunohistochemistry, and ELISA workflows performed on Human, Mouse, and Rat samples. The unconjugated reagent is supplied in a 100 µl vial of rabbit polyclonal antiserum, compatible with standard HRP- or fluorophore-conjugated secondary reagents for chromogenic or immunofluorescence detection. Investigators studying developmental signaling, T-cell lineage commitment, and oncogenic Notch activity use this antibody to map receptor cleavage events in cell culture lysates and paraffin-embedded tissue sections.