Anti-Cleaved-MMP-14 (Y112) Antibody

Generated in rabbit and supplied by Antibodies.com as an unconjugated polyclonal reagent, this antibody targets the Y112 cleaved form of matrix metalloproteinase 14 (MMP-14 / MT1-MMP), a membrane-anchored collagenase central to extracellular matrix turnover, tumor invasion, and angiogenic signaling.

The product is provided at 1 mg/ml in PBS with 0.1% sodium azide and 50% glycerol, packaged as a 100 µl vial containing ample volume for routine Western blot workflows on human, mouse, and rat samples. For best stability, store aliquots at -20 °C and limit freeze-thaw cycles; the glycerol cryoprotectant helps preserve antibody activity under refrigerated handling.

Because the epitope maps to the catalytically activated cleavage site rather than the full-length zymogen, the reagent distinguishes active MMP-14 from its latent precursor, supporting research into pericellular proteolysis, cancer cell migration, and tissue remodeling pathways in vitro and in vivo.