Anti-Cleaved-ITI-H1 (D672) Antibody

Raised in rabbit, this polyclonal antibody from Antibodies.com targets the cleaved fragment of inter-α-trypsin inhibitor heavy chain H1 (ITI-H1) generated by proteolytic cleavage at aspartate residue 672. The reagent is supplied at 1 mg/ml in PBS with 0.1% sodium azide and 50% glycerol, packaged as 100 µl suitable for multiple Western blot experiments. Validated for Western blot detection in human, mouse, and rat samples, the unconjugated format allows flexible pairing with HRP, fluorophore, or biotin-labeled secondary reagents. Cleavage of ITI-H1 at D672 occurs during acute-phase inflammatory responses and liberates the bikunin light chain while leaving a heavy chain remnant that can be tracked in serum and tissue lysate preparations. Researchers studying extracellular matrix stabilization, protease cascades, sepsis-associated biomarkers, or inflammatory signaling pathways rely on this reagent to monitor disease progression or experimental intervention. For storage, keep the antibody at -20 °C in working aliquots to preserve activity and avoid repeated freeze-thaw cycles; the 0.1% sodium azide prevents microbial contamination of the stock vial.