Anti-Cleaved-Caspase-8 (D384) Antibody

Specifically recognizing the catalytically active subunit of human caspase-8 generated by cleavage at the D384 site, this unconjugated rabbit polyclonal antibody from Antibodies.com supports Western blot and ELISA workflows on lysates from cell culture and primary tissue specimens. Researchers use this reagent to monitor initiation of extrinsic apoptosis through death receptor signaling downstream of Fas, TRAIL, and tumor necrosis factor receptors, and to track initiator caspase activation in studies of immune regulation, neurodegeneration, and cancer therapy response. Because the antibody is supplied unconjugated in a 100 µl vial, it can be paired with HRP, biotin, fluorophore, or bead-based detection chemistries chosen to match downstream assay design. For handling, the reagent should be aliquoted upon arrival, stored frozen at -20 °C, protected from light, and limited to a small number of freeze-thaw cycles to preserve antigen-binding capacity over time. Intended for research use only.