Anti-Cleaved-Caspase-6 p18 (D162) Antibody

Raised in rabbit, this unconjugated polyclonal antibody selectively detects the cleaved p18 subunit of caspase-6 generated at the D162 cleavage site, a hallmark of caspase-6 activation during apoptotic signaling. The reagent is supplied as 100 µl of antiserum and is validated for Western blot, immunohistochemistry, and ELISA workflows with mouse and rat samples. Because the immunogen corresponds to the neo-epitope revealed only after proteolytic processing, the antibody preferentially reports the catalytically active enzyme rather than the inactive zymogen, making it well-suited to apoptosis research, neurodegeneration studies, and investigations of executioner caspase cascades. Provided by Antibodies.com as an unconjugated primary antibody, the reagent carries no fluorophore or enzyme label, allowing users to pair it with their preferred secondary detection chemistry for chromogenic, fluorescent, or amplified readouts.