Anti-Cleaved-Caspase-3 p17 (D175) Antibody

This rabbit polyclonal reagent from Antibodies.com specifically detects the catalytically active p17 subunit of caspase-3 generated by cleavage at aspartate 175, a hallmark event in apoptotic signaling. The antibody is validated for western blot, immunohistochemistry, and ELISA workflows across human, mouse, and rat samples, supporting apoptosis studies in cell culture, tumor xenografts, and tissue sections. Each vial is supplied unconjugated at 100 µl, providing ample reagent for routine immunoblotting and IHC experiments that probe executioner caspase activation in neuronal injury, cancer cell death, and developmental biology research. Scientists investigating chemotherapy-induced apoptosis, ischemic damage, or neurodegenerative disease pathways rely on cleaved-caspase-3 detection as a definitive marker of programmed cell death commitment.