Anti-CLDN4 Antibody

This rabbit polyclonal primary antibody from Antibodies.com specifically targets CLDN4 (Claudin-4), a roughly 22 kDa transmembrane tight junction component expressed across epithelial barriers. Raised in rabbit and supplied as an unconjugated IgG preparation, the reagent is validated for Western blot and immunohistochemistry workflows on human and mouse samples. The 200 µl aliquot supports multiple membrane and tissue staining experiments, and the unconjugated format allows flexible pairing with HRP- or fluorophore-conjugated secondary reagents chosen by the laboratory's preferred detection chemistry.

Claudin-4 has emerged as a marker of interest in epithelial biology and oncology research, including studies of ovarian, breast, pancreatic, and gastrointestinal tumors where its expression pattern is altered relative to surrounding tissue. Because CLDN4 also functions as the cellular receptor for Clostridium perfringens enterotoxin, this reagent is frequently used to investigate tight junction integrity, paracellular barrier function, and receptor-mediated pathogenesis. The polyclonal nature of the antibody increases the likelihood of recognising multiple epitopes on the target, which can be advantageous when working with formalin-fixed paraffin-embedded tissue sections in immunohistochemistry, and with denatured protein lysates on Western blot membranes. Supplied for research use only, the antibody offers cross-species reactivity that lets researchers compare normal and diseased epithelial samples within a single experimental series.