Anti-CLDN3 Antibody

Claudin-3 (CLDN3) is a ~23 kDa four-pass transmembrane tight junction protein that forms the structural backbone of epithelial paracellular seals in mammalian tissues. This rabbit polyclonal antibody from Antibodies.com is raised against human CLDN3 and supplied as 100 µl of unconjugated antiserum, validated for Western blot and immunohistochemistry on human samples.

In research applications, CLDN3 expression and localization are used as markers of epithelial barrier integrity and have been investigated in ovarian, colorectal, and breast cancer tissue studies, where altered tight junction architecture correlates with tumor progression. The reagent performs on formaldehyde-fixed paraffin-embedded sections in standard IHC protocols and on nitrocellulose or PVDF membranes in Western blot workflows, with a single expected band near the predicted molecular weight.

Each vial is supplied ready for research use only workflows including immunohistochemistry and Western blot, and the unconjugated format allows flexible secondary antibody pairing for fluorescence or enzymatic detection.