Anti-CLDN2 Antibody

Tight junction biology research depends on discriminating between more than 20 human claudin family members, and this unconjugated rabbit polyclonal reagent is raised specifically against claudin-2 (CLDN2). Marketed by Antibodies.com, the antibody is supplied as a 50 µl liquid IgG fraction validated on human samples and is intended for immunofluorescence (IF) workflows on fixed cells and tissue sections, where it labels the apical tight junction complexes of polarized epithelia.

CLDN2 is a pore-forming tight junction protein enriched in kidney proximal tubules, small intestinal enterocytes, and hepatocytes, and changes in its expression have been linked to hepatocellular carcinoma, colorectal cancer, and inflammatory bowel disease, so this reagent supports studies of epithelial barrier integrity, paracellular cation and water transport, and tumor progression.

The unconjugated format allows pairing with user-selected fluorophore-conjugated secondary antibodies for flexible multiplex imaging, and the preparation should be stored refrigerated in single-use aliquots to preserve activity across repeated staining runs.