Anti-CLDN2 Antibody

Produced in rabbit and supplied by Antibodies.com as 200 µl of unconjugated polyclonal IgG, this reagent targets CLDN2 (claudin-2), a tight junction membrane protein that forms cation-selective paracellular pores in leaky epithelia including kidney proximal tubules and small intestinal enterocytes. Validated for immunofluorescence (IF) on human samples, the antibody enables visualization of claudin-2 localization in epithelial monolayers, tumor tissue sections, and cell culture models of barrier function. CLDN2 expression is frequently altered in colorectal carcinoma, inflammatory bowel disease, and hepatocellular carcinoma, supporting research into epithelial permeability, tight junction remodeling, and oncogenic signaling. The polyclonal format provides broader epitope coverage than monoclonal alternatives, ensuring consistent detection across denatured and native claudin-2 conformations. Aliquot upon receipt and avoid repeated freeze-thaw cycles to preserve binding activity.