Anti-CLDN2 Antibody

This rabbit polyclonal reagent from Antibodies.com targets Claudin-2 (CLDN2), a ~23 kDa transmembrane tight-junction protein that forms paracellular cation-selective pores in leaky epithelia of the kidney proximal tubule, liver bile ducts, and intestinal lining. Raised in rabbit, the IgG isotype antibody is supplied as 100 µl of unconjugated product and is validated for immunofluorescence (IF) detection on human samples, making it a practical tool for studying barrier permeability in hepatology, nephrology, and gastrointestinal research.

CLDN2 expression is frequently altered in hepatocellular carcinoma, colorectal tumors, and inflammatory bowel disease, where it is investigated as a marker of disrupted tight-junction integrity and epithelial remodeling. The polyclonal format allows recognition of multiple epitopes, which is useful when working with formalin-fixed paraffin sections or cultured epithelial monolayers.

For handling, store at -20 °C in working aliquots to minimize freeze-thaw cycles, and protect from light for long-term antibody stability.