Anti-CLDN19 Antibody

Produced as an unconjugated rabbit polyclonal reagent by Antibodies.com, this anti-CLDN19 antibody supports research into paracellular ion transport across renal and retinal epithelia. The IgG reagent is supplied at 50 µl volume and validated for Western blot (WB) detection in human, mouse, and rat samples.

CLDN19 (claudin-19) is a transmembrane tight junction protein that assembles heteromeric strands with CLDN16 in the thick ascending limb of the kidney's loop of Henle, where it governs magnesium and calcium reabsorption. Antibody-based detection therefore aids investigations into familial hypomagnesemia with hypercalciuria and nephrocalcinosis (FHHNC), as well as ocular phenotypes associated with CLDN19 loss-of-function variants.

Researchers examining tight junction integrity, paracellular permeability, and tissue-specific expression patterns can apply this polyclonal reagent in standard immunoblotting workflows, including SDS-PAGE protein separation and chemiluminescent readout on nitrocellulose or PVDF membranes. Cross-reactivity across the listed species enables comparative studies in rodent disease models and human patient-derived samples.