Anti-CLDN14 Antibody

Produced in rabbit as an IgG polyclonal reagent, this unconjugated primary antibody targets CLDN14, a tight junction transmembrane protein of the claudin family. CLDN14 contributes to paracellular ion permeability in epithelial tissues, with established roles in renal magnesium reabsorption within the thick ascending limb of Henle and in inner ear function, where loss-of-function variants underlie autosomal recessive nonsyndromic hearing loss. Antibodies.com supplies the reagent as 200 µl of liquid validated for Western blot detection of endogenous CLDN14 in human and mouse tissue lysates or cell extracts. For long-term use, aliquot the antibody to limit freeze-thaw cycles and protect from light. Researchers investigating epithelial barrier biology, ion transport in the kidney, or genetic deafness can deploy this reagent to probe CLDN14 expression by immunoblotting.