Anti-CLDN14 Antibody

Claudin-14 is a four-transmembrane-domain tight junction protein most prominently expressed in the epithelium of the inner ear and the renal tubule, where it regulates paracellular ion permeability. Loss-of-function mutations in CLDN14 are causally linked to autosomal recessive nonsyndromic hearing loss (DFNB29), while variants that alter its expression are associated with hypercalciuria and an increased risk of calcium-based kidney stone formation. This reagent from Antibodies.com is a rabbit polyclonal IgG antibody raised against human CLDN14, supplied as 50 µl of unconjugated antisera and validated for Western Blot detection of the endogenous protein. Researchers studying epithelial barrier function, auditory hair cell biology, or renal calcium handling can use it to probe claudin-14 levels in cell lysates and tissue homogenates, with the unconjugated format allowing flexible pairing with HRP- or fluorophore-conjugated secondary reagents of the user's choice.