Anti-CLDN11 Antibody

This unconjugated rabbit polyclonal antibody targets CLDN11 (claudin-11), a roughly 22 kDa transmembrane tight-junction protein also known as oligodendrocyte-specific protein (OSP). CLDN11 contributes to the radial component of central nervous system myelin and to paranodal axoglial junctions, and it is also a structural component of the blood-testis barrier through Sertoli cell tight junctions. Each vial contains 100 µL of antiserum validated for Western blot, immunohistochemistry, and immunofluorescence on human, mouse, and rat samples, with the unconjugated format suited to secondary-antibody multiplexing and custom labeling. Investigators working on oligodendrocyte biology, myelination, male reproductive function, autoimmune demyelination models such as experimental autoimmune encephalomyelitis, and tight-junction signaling in epithelial and endothelial barriers use this reagent to localize the protein at cell-cell contacts and to track expression across developmental and pathological states. Store the vial refrigerated at 4 °C for short-term use; for longer storage, aliquot and freeze at -20 °C and protect from light to preserve reactivity through repeated experiments while limiting freeze-thaw damage. The Antibodies.com polyclonal is raised in rabbit and recognizes multiple epitopes on the target, supporting robust detection across the listed applications.