Anti-CLDN1 Antibody

This rabbit polyclonal antibody from Antibodies.com recognizes Claudin-1 (CLDN1), a ~22 kDa four-transmembrane-domain tight-junction protein that seals the paracellular space between adjacent epithelial cells. Supplied unconjugated at 100 µl per vial, the reagent is validated for western blot and immunohistochemistry across human, mouse, and rat specimens.

Claudin-1 maintains the integrity of the epidermal, intestinal, and hepatic barriers, and its loss or mislocalization is a hallmark of atopic dermatitis, inflammatory bowel disease, cholestatic liver injury, and the epithelial-mesenchymal transition that drives metastasis in solid tumors. The target also draws sustained interest in virology: Claudin-1 serves as a co-receptor that enables hepatitis C virus entry into hepatocytes alongside CD81 and SR-B1. Researchers apply this antibody to map tight-junction remodeling in wound-healing models, profile barrier disruption in leaky-gut studies, and survey patient-derived tissue microarrays for claudin expression patterns.

Aliquot on arrival and store at -20 °C to preserve activity; limit freeze-thaw cycles to maintain titer. For active bench use, keep refrigerated with a suitable preservative. Intended for research use only.