Anti-CLCN5 Antibody

Raise detection of the voltage-gated chloride channel ClC-5 with this polyclonal reagent from Antibodies.com, formatted for western blot and immunohistochemistry workflows. Produced in rabbit and supplied as 100 µl of unconjugated antiserum, the antibody targets an intracellular epitope of CLCN5, a protein predominantly studied in renal proximal tubule endosomes where it supports chloride conductance and endosomal acidification. Mutations in the underlying gene are linked to Dent disease type 1 and low-molecular-weight proteinuria, so this reagent is commonly used to probe kidney tissue and cultured mammalian cell lines for changes in channel expression, trafficking, or subcellular distribution. Antibodies.com validates reactivity across human, mouse, and rat samples, enabling cross-species studies in models of proximal tubule dysfunction and inherited nephrolithiasis. The polyclonal nature of the reagent provides recognition of multiple epitopes along the channel, useful when endogenous expression is low or when working with archival formalin-fixed material.