Anti-Claudin-7 (S204) Antibody

This rabbit polyclonal antibody from Antibodies.com targets Claudin-7, a tetraspan tight junction protein that forms paracellular strands and barrier seals in epithelial and endothelial tissues. The reagent is supplied as 100 µl at 1 mg/ml in phosphate buffered saline (PBS) with 0.05% sodium azide at approximately pH 7.2, and is unconjugated for flexible pairing with secondary detection reagents in user-defined workflows.

Validated applications include Western blot for protein-level expression profiling in cultured cells and tissue lysates, and immunohistochemistry (IHC) on fixed sections to localize Claudin-7 at epithelial junctions. The antibody has been confirmed to react with human, mouse, and rat samples, supporting comparative work across cell line panels and rodent model systems.

Claudin-7 is of interest in epithelial barrier biology, mucosal transport studies, and cancer research, where altered expression and mislocalization have been documented in breast, gastric, esophageal, and colorectal carcinomas. For storage, keep the vial refrigerated and protected from light; aliquot upon receipt to minimize freeze-thaw cycles when long-term use is planned.