Anti-Claudin 7 Antibody

This rabbit polyclonal antibody targets Claudin 7, a transmembrane tight junction protein that helps maintain epithelial barrier integrity and paracellular permeability across mucosal surfaces. Raised in rabbit and supplied as an unconjugated preparation, the reagent is validated for Western blot and immunohistochemistry workflows and reacts with Human, Mouse, and Rat samples, supporting translational studies that span rodent disease models and matched human tissue archives.

The 100 µl format is intended for research use only, with each aliquot providing enough reagent for multiple blotting membranes or stained tissue sections depending on dilution. Claudin 7 expression is frequently examined in colorectal, gastric, esophageal, and breast cancer research, where its downregulation or mislocalization has been associated with tumor progression and altered cell adhesion. The polyclonal nature of the antibody broadens recognition across multiple epitopes on the target, which can be useful when probing samples where post-translational modifications or partial proteolysis may mask individual binding sites.

Supplied by Antibodies.com as a primary antibody reagent, this Claudin 7 reagent fits into standard immunodetection pipelines that pair the primary incubation with HRP- or fluorophore-conjugated secondary antibodies for chemiluminescent or fluorescent readout.