Anti-Claudin 5 Antibody

Produced in rabbit as a polyclonal immunoglobulin preparation, this unconjugated primary antibody targets the tight-junction transmembrane protein Claudin 5 (CLDN5), a ~23 kDa tetraspan membrane component most strongly expressed by endothelial cells of cerebral microvessels and a widely used marker of blood–brain barrier integrity. Researchers apply it in western blot and immunohistochemistry workflows on human, mouse, and rat samples to investigate vascular barrier function, ischemic stroke models, glioblastoma and other CNS pathologies with disrupted tight junctions, inflammatory neurovascular damage, and developmental angiogenesis. Each vial from Antibodies.com ships as 100 µl of polyclonal antibody; aliquots should be handled according to standard storage and freeze-thaw practices to preserve binding activity through the indicated shelf life.