Anti-Claudin 3 Antibody

The Claudin 3 tight junction protein is a tetraspan transmembrane component of epithelial and endothelial barriers, encoded by the CLDN3 gene and weighing roughly 23 kDa. Antibodies.com offers a rabbit polyclonal primary antibody raised against this target, supplied as an unconjugated reagent at 100 µl volume. Validated applications include Western blot, immunohistochemistry, and immunofluorescence on human tissue and cell samples, making it useful for studies of paracellular permeability, epithelial polarity, and tight junction remodeling in organs such as the gut, kidney, and mammary gland. The reagent is also commonly cited in oncology research investigating altered Claudin 3 expression in epithelial-derived tumors including ovarian and breast carcinomas. As a polyclonal reagent, it can tolerate minor epitope variations and support multi-round staining protocols. Store the vial refrigerated and protect from light, aliquoting after first thaw to limit freeze-thaw damage to the antiserum.