Anti-Claudin 1 Antibody

This rabbit polyclonal primary antibody from Antibodies.com is raised against Claudin 1, a transmembrane tight-junction protein that seals the paracellular space between adjacent epithelial cells. By recognizing epitopes shared by human, mouse, and rat Claudin 1, the reagent supports cross-species studies of epithelial barrier integrity, dermal and intestinal permeability, and epithelial-mesenchymal transition in tumor biology research.

Supplied as 100 µl of unconjugated antiserum, the antibody has been validated for Western blot (WB) and immunohistochemistry (IHC), giving laboratories flexibility to detect endogenous Claudin 1 in tissue sections and whole-cell lysates without a pre-conjugated reporter. Polyclonal reactivity broadens epitope coverage on the target, which is useful when probing Claudin 1 variants implicated in hepatocellular carcinoma invasion and hepatitis C virus entry into hepatocytes.

Common applications include mapping tight-junction organization in intestinal, renal, and hepatic epithelia, characterizing epidermal barrier defects in dermatitis models, and profiling Claudin 1 expression as a marker of epithelial phenotype in tumor samples.