Anti-CKS1B Antibody

Raised in rabbit and supplied as an unconjugated IgG polyclonal preparation, this Antibodies.com reagent targets CKS1B (CDC28 protein kinase regulatory subunit 1B), a cyclin-dependent kinase binding protein that drives the G1/S transition by promoting ubiquitin-dependent degradation of the p27 tumor suppressor. Validated for Western blot detection on lysates from human, mouse, and rat origin, the antibody supports studies of cell cycle dysregulation, mitotic checkpoint control, and oncogenic signaling cascades linked to multiple myeloma, hepatocellular carcinoma, and breast cancer. The 200 µl vial format is intended for research use only, and the polyclonal nature of the reagent allows recognition of multiple epitopes on the CKS1B protein, which is helpful when probing post-translational modifications or splice variants that may be missed by monoclonal alternatives. Researchers investigating Skp2-CKS1B-p27 axis activity, gene amplification at the 1q21 locus, or proteasome-mediated cell cycle progression frequently use this reagent alongside kinase assays and co-immunoprecipitation workflows to map CKS1B interactions within CDK2-containing complexes.