Anti-CKMT2 Antibody

CKMT2 encodes mitochondrial creatine kinase, the sarcomeric isoform (sMtCK) that resides in the intermembrane space of mitochondria and powers the phosphocreatine energy shuttle in tissues with high, fluctuating energy demand. Skeletal and cardiac muscle are the principal expression sites, where the enzyme couples oxidative phosphorylation to cytosolic ATP regeneration by moving a high-energy phosphate bond between the mitochondrial and cytosolic creatine pools.

This polyclonal reagent from Antibodies.com is raised in rabbit, supplied unconjugated in a 100 µL volume, and has been validated for Western blot and immunofluorescence across human, mouse, and rat samples. It is commonly used to study muscle bioenergetics, mitochondrial respiratory chain function, and the subcellular distribution of sarcomeric mitochondria. Published work on CKMT2 knockout mice reports impaired muscle contractile performance together with altered mitochondrial morphology, and reduced CKMT2 protein abundance has been described in skeletal muscle under cachectic and disuse conditions, making this antibody a practical tool for tracking protein-level changes by WB and intracellular localization by IF in those experimental contexts.