Anti-CHUK Antibody

Produced in rabbit and purified as an unconjugated polyclonal antiserum, this CHUK antibody from Antibodies.com is raised against the catalytic alpha subunit of the IKK complex (also called IKK-α or Conserved Helix-Loop-Helix Ubiquitous Kinase), the serine/threonine kinase that phosphorylates IκBα to liberate NF-κB and drive transcription of immune and survival genes. The 100 µl vial is validated across four orthogonal readouts — Western blot, immunohistochemistry, immunofluorescence, and immunoprecipitation — on human samples, supporting studies of innate immunity, inflammatory cytokine signaling, and oncogenic NF-κB activity in cell lysates or fixed tissue sections. For best results, aliquot upon first use to limit freeze-thaw cycles and store frozen; the reagent is shipped on cold packs. Researchers investigating TNF receptor signaling, B-cell receptor cross-talk, or DNA-damage-induced NF-κB activation routinely deploy CHUK/IKK-α immunoblots to confirm complex integrity and pathway engagement in both basic immunology and translational oncology workflows.