Anti-CHRNA2 Antibody

The CHRNA2 (Cholinergic Receptor Nicotinic Alpha 2 Subunit) is a ligand-gated ion channel component widely expressed in neuronal tissue, where it assembles with other nicotinic subunits to form acetylcholine-gated channels that mediate fast synaptic transmission and modulate neurotransmitter release. This polyclonal antibody from Antibodies.com is raised in rabbit and supplied as an unconjugated IgG preparation, giving researchers flexibility to choose their own detection chemistry, secondary antibody, or labeling strategy.

Validated specifically for western blot, the reagent detects the rat CHRNA2 protein in tissue and cell lysates. Each vial contains 200 µL of antibody, typically enough for several membranes when used at standard working dilutions. The polyclonal format recognizes multiple epitopes on the target, which can improve signal robustness in blotting applications where the antigen may be partially denatured or present in low abundance.

CHRNA2 has been implicated in studies of autosomal dominant nocturnal frontal lobe epilepsy, autonomic ganglion signaling, and the modulation of dopaminergic pathways relevant to addiction research. Investigators working on nicotinic receptor expression, subunit composition, or regulation in rat models will find this reagent useful for protein-level validation alongside transcriptomic or electrophysiological approaches. Store refrigerated and avoid repeated freeze-thaw cycles to preserve antibody activity over the working shelf life.