Anti-CHRNA2 Antibody

This polyclonal antibody from Antibodies.com targets the cholinergic receptor nicotinic alpha 2 subunit (CHRNA2), an ion channel component that contributes to fast synaptic transmission in the peripheral and central nervous system. Raised in rabbit, the reagent is supplied as 100 µl of IgG in unconjugated format, ready for use in immunodetection workflows with rat-derived samples. Validation has been performed for Western blot, where the antibody detects the endogenous receptor subunit in membrane and cytoplasmic fractions prepared from rat tissue homogenates.

CHRNA2 assembles with other nicotinic subunits (commonly β2 or β4) to form functional heteromeric receptors that respond to acetylcholine. Researchers studying cholinergic signaling, autonomic ganglia function, or ligand-gated ion channel pharmacology use this reagent to profile expression patterns and to confirm knockdown or overexpression in cellular and animal models. The unconjugated IgG format supports flexible detection chemistry, allowing users to pair the primary with HRP, fluorophore, or biotin-labeled secondary reagents of their choice.

For best results, keep the vial refrigerated and avoid repeated freeze-thaw cycles; aliquot upon first use to preserve antibody activity. This product is intended for research use only and is not approved for diagnostic or therapeutic applications.