Anti-CHRM1 Antibody

This rabbit polyclonal antibody targets CHRM1 (Muscarinic acetylcholine receptor M1), a G protein-coupled receptor central to cholinergic signaling in the central nervous system. Produced by Antibodies.com as an unconjugated reagent, it ships in a 100 µl volume and is validated for Western blot (WB) and immunohistochemistry (IHC) workflows.

CHRM1 is broadly expressed across cortical, hippocampal, and striatal neurons, where it mediates slow excitatory postsynaptic potentials and modulates learning, memory, and synaptic plasticity. The reagent shows reactivity against human, mouse, and rat samples, enabling cross-species studies relevant to Alzheimer's disease, schizophrenia, and cholinergic pharmacology research.

Its polyclonal design recognizes multiple epitopes on the M1 receptor, providing stronger signal and greater tolerance to minor antigen variation than monoclonal alternatives. The unconjugated format offers flexibility in pairing with custom secondary antibodies or detection labels across varied assay platforms.

Typical uses include Western blot detection of the approximately 51 kDa CHRM1 band in cell and tissue lysates, and IHC staining of brain sections to map receptor distribution. For long-term stability, store refrigerated and divide into working aliquots to limit freeze-thaw cycles.