Anti-CHRFAM7A Antibody

Targeting the CHRFAM7A fusion protein, this rabbit polyclonal reagent from Antibodies.com is supplied as a 50 µl vial of unconjugated IgG, affinity-purified for Western blot and immunohistochemistry workflows on human, mouse, and rat samples.

CHRFAM7A is a uniquely human hybrid gene arising from partial duplication of CHRNA7 on chromosome 15 fused with the FAM7A locus; its truncated protein product is predicted at roughly 46 kDa and acts as a dominant-negative modulator of the α7 nicotinic acetylcholine receptor, a ligand-gated ion channel implicated in fast synaptic signaling.

Investigators deploy this reagent to study cholinergic regulation in neuroinflammation, schizophrenia, bipolar disorder, and Alzheimer's disease, probing both neural tissue and peripheral blood lymphocytes where CHRFAM7A is expressed in epithelial and immune cell populations.

Vials ship refrigerated and should be aliquoted for long-term storage at -20 °C to limit freeze-thaw cycles. Intended for research use only and not for diagnostic or therapeutic applications.