Anti-CHRDL1 Antibody

This unconjugated rabbit polyclonal antibody recognizes human Chordin-like 1 (CHRDL1), a secreted bone morphogenetic protein (BMP) antagonist that modulates BMP4 activity during embryogenesis. The reagent is supplied as 100 µl and is validated for Western blot (WB) and immunohistochemistry (IHC) on human samples, supporting detection of the endogenous protein in cell lysates and fixed tissue sections.

CHRDL1 plays a documented role in neural crest induction, retinal development, and ocular size regulation. Loss-of-function mutations in the CHRDL1 gene cause X-linked megalocornea (MGC1), and altered expression has been reported in colorectal cancer xenograft models and in chondrocyte differentiation studies. Researchers in developmental biology, ophthalmology, and cancer biology turn to anti-CHRDL1 reagents from Antibodies.com to map BMP-pathway activity in normal and diseased tissue.