Anti-CHOP Antibody

Endoplasmic reticulum stress research depends on reliable markers for the unfolded protein response, and CHOP (also known as DDIT3 and GADD153) sits at the center of that pathway as the transcription factor driving ER stress-induced apoptosis. This rabbit polyclonal reagent from Antibodies.com is raised against C/EBP homologous protein and supplied as an unconjugated 100 µl aliquot validated for western blot, immunohistochemistry, immunofluorescence, and ELISA across human and mouse samples. Investigators working on PERK/eIF2α/ATF4 signaling, translational control, or mitochondrial dysfunction rely on CHOP immunodetection to follow caspase activation and cell fate decisions in disease models spanning diabetes, neurodegeneration, and tumor hypoxia. The polyclonal format provides broader epitope coverage than monoclonal alternatives, raising the chance of detecting both full-length CHOP and any truncated isoforms produced under sustained stress. Aliquot upon arrival and freeze in working volumes to limit freeze-thaw cycles and preserve binding activity.