Anti-CHN1 Antibody

CHN1 encodes chimerin 1, a brain-enriched GTPase-activating protein that switches off Rac1 and remodels the actin cytoskeleton during axon guidance and neuronal migration. Mutations in this gene are linked to Duane's retraction syndrome (DURS2), a congenital eye-movement disorder, making the protein a frequent target in neurodevelopment and ocular-motor research.

This unconjugated rabbit polyclonal IgG from Antibodies.com is supplied as 50 µl of liquid in a single vial, raised against human chimerin 1 and affinity-purified so it yields clean bands on western blot and clean signal in immunohistochemistry on fixed tissue sections. Validated reactivity on human, mouse, and rat samples lets one antibody move across standard mammalian models, from cultured neurons to rodent brain sections. Store the vial at -20°C as a working aliquot and avoid repeated freeze-thaw cycles to preserve binding activity. Applications: WB, IHC. Host: Rabbit. Isotype: IgG. Conjugate: Unconjugated.