Anti-CHML Antibody

CHML encodes Rab escort protein 2 (REP-2), a cytosolic factor that presents Rab GTPases to Rab geranylgeranyltransferase for C-terminal prenylation, a lipid modification essential for membrane attachment and intracellular vesicular trafficking. This unconjugated rabbit polyclonal antibody from Antibodies.com is raised against CHML and validated for Western blot and immunohistochemistry on human samples.

Supplied as 100 µl of liquid antiserum in a vial, the reagent supports research use only investigations of Rab prenylation, choroideremia-related pathways, and membrane transport biology. The host species is rabbit, the clonality is polyclonal, and the conjugate is unconjugated, leaving the choice of secondary label open to the end user. Reactivity is reported for human tissue; cross-reactivity with mouse, primate, or other species has not been formally established in the manufacturer datasheet.

Working dilutions should be optimised empirically against a positive control tissue or cell line known to express REP-2. Store refrigerated at the temperature indicated on the accompanying data sheet, and avoid repeated freeze-thaw cycles to preserve antibody activity.