Anti-Chk2 (S62) Antibody

Checkpoint Kinase 2 (Chk2) phosphorylated at serine 62 is the specific target of this rabbit polyclonal reagent, which detects the active form of the kinase within the ATM-dependent DNA damage signaling cascade. Researchers studying genotoxic stress, cell cycle checkpoints, double-strand break repair, and tumor suppressor biology rely on phospho-specific antibodies to monitor pathway activation in response to irradiation, chemotherapeutic agents, or replication stress.

From Antibodies.com, the unconjugated antibody is supplied as a 100 µl pack at 1 mg/ml in phosphate buffered saline (pH 7.2) containing 0.05% sodium azide. The polyclonal host format increases the chance of recognizing the phosphorylated epitope across different protein preparations, and the reagent is validated for Western blot and immunohistochemistry on human, mouse, and rat samples.

For best results, refrigerate the vial upon arrival; for extended storage, aliquot and freeze at -20°C while avoiding repeated freeze-thaw cycles. The sodium azide–containing buffer permits use in many downstream staining and blotting workflows without further preparation. This is a research use only reagent, intended for laboratory studies of DNA damage response signaling.