Anti-Chk2 (S379) Antibody

Phospho-specific detection of Checkpoint Kinase 2 (Chk2) at serine 379 is provided by this rabbit polyclonal reagent from Antibodies.com, raised against an activation-loop autophosphorylation site involved in DNA damage signaling. Following double-strand breaks, ATM phosphorylates Chk2 at threonine 68, triggering dimerization and trans-autophosphorylation at sites including S379, which contributes to full kinase activation, substrate recruitment, and downstream cell cycle arrest.

The unconjugated antibody is supplied as 100 µl at 1 mg/ml in phosphate buffered saline with 0.05% sodium azide, intended for western blot and immunohistochemistry workflows on human, mouse, and rat samples. Store refrigerated at 4°C for short-term use; for longer periods, aliquot and freeze to preserve antibody activity. Each vial is for research use only, supporting studies in genotoxic stress response, checkpoint control, and tumor suppressor biology.