Anti-CHD5 Antibody

This rabbit polyclonal IgG reagent from Antibodies.com targets CHD5 (Chromodomain Helicase DNA-binding protein 5), a chromatin-remodeling factor encoded on human chromosome 1p36.31 and studied extensively as a tumor suppressor in neural crest-derived tissues. Supplied as an unconjugated liquid at 200 µl per vial, the antibody is validated for Western blot detection of the human CHD5 protein and recognizes endogenous expression in cell lysates and tissue extracts. CHD5 assembles into the NuRD transcriptional repression complex and influences cell-cycle progression, senescence, and differentiation pathways that are commonly disrupted in neuroblastoma and several adult carcinomas. Researchers use this reagent to probe CHD5 steady-state levels, confirm 1p36 deletion status by loss of protein signal, and follow dynamic regulation following DNA damage or oncogenic stress. The polyclonal format offers an epitope pool that supports detection of full-length CHD5 isoforms and is suited to immunoblotting applications where recognition of multiple regions improves band reliability on SDS-PAGE. Standard short-term handling at 4°C is recommended, with aliquoting for longer-term storage to preserve activity across repeated freeze-thaw cycles. Each lot is quality-controlled for specificity against the human target, and the antibody is intended for research use only in basic and translational investigations of chromatin biology and tumor suppression.